Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents

• Asıl Yazarlar: Chongwen Bi (Yazar), Cheng Ye (Yazar), Yinghong Li (Yazar), Wuli Zhao (Yazar), Rongguang Shao (Yazar), Danqing Song (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2016-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Taking 12-N-p-chlorobenzyl sophoridinol 2 as a lead, a series of novel sophoridinic derivatives with various 3'-substituents at the 11-side chain were synthesized and evaluated for their anticancer activity from sophoridine (1), a natural antitumor medicine. Among them, the sophoridinic ketones...