Synthesis and biological evaluation of 12-N-p-chlorobenzyl sophoridinol derivatives as a novel family of anticancer agents

Taking 12-N-p-chlorobenzyl sophoridinol 2 as a lead, a series of novel sophoridinic derivatives with various 3'-substituents at the 11-side chain were synthesized and evaluated for their anticancer activity from sophoridine (1), a natural antitumor medicine. Among them, the sophoridinic ketones...

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Main Authors: Chongwen Bi (Author), Cheng Ye (Author), Yinghong Li (Author), Wuli Zhao (Author), Rongguang Shao (Author), Danqing Song (Author)
Format: Book
Published: Elsevier, 2016-05-01T00:00:00Z.
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