In silico and antithrombotic studies of 1,3,4-oxadiazoles derived from benzimidazole

• প্রধান লেখক: B. Vishwanathan (লেখক), B. M. Gurupadayya (লেখক), K. Venkata Sairam (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Bangladesh Pharmacological Society, 2015-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In the present study, a series of 1,3,4-oxadiazole derivatives (4a-4k) derived from benzimidazole were docked onto factor Xa (PDB: 1NFY) protein using SYBYLX 2.1. and also evaluated for in vitro clot lysis for thrombolytic activity. The synthesized molecules were also screened for in silico ADME stu...