A novel 16-gene alternative mRNA splicing signature predicts tumor relapse and indicates immune activity in stage I-III hepatocellular carcinoma

• Main Authors: Xu-Xiao Chen (Author), Bao-Hua Zhang (Author), Yan-Cen Lu (Author), Zi-Qiang Li (Author), Cong-Yan Chen (Author), Yu-Chen Yang (Author), Yong-Jun Chen (Author), Di Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Hepatocellular carcinoma (HCC) is a lethal disease with high relapse and dismal survival rates. Alternative splicing (AS) plays a crucial role in tumor progression. Herein, we aim to integratedly analyze the relapse-associated AS events and construct a signature predicting tumor relapse...