Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice

• Main Authors: Sabela Diaz-Castroverde (Author), Almudena Gómez-Hernández (Author), Silvia Fernández (Author), Gema García-Gómez (Author), Marianna Di Scala (Author), Gloria González-Aseguinolaza (Author), Elisa Fernández-Millán (Author), Águeda González-Rodríguez (Author), María García-Bravo (Author), Pierre Chambon (Author), Carmen Álvarez (Author), Liliana Perdomo (Author), Nuria Beneit (Author), Oscar Escribano (Author), Manuel Benito (Author)
• Format: Book
• Published: The Company of Biologists, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type 2 diabetes mellitus is a complex metabolic disease and its pathogenesis involves abnormalities in both peripheral insulin action and insulin secretion. Previous in vitro data showed that insulin receptor isoform A, but not B, favours basal glucose uptake through its specific association with en...