Design, synthesis and evaluation of quinoline-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease

• Main Authors: Hongsong Chen (Author), Jing Mi (Author), Sen Li (Author), Zhengwei Liu (Author), Jing Yang (Author), Rui Chen (Author), Yujie Wang (Author), Yujuan Ban (Author), Yi Zhou (Author), Wu Dong (Author), Zhipei Sang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel quinoline-O-carbamate derivatives was rationally designed for treating Alzheimer's disease (AD) by multi-target-directed ligands (MTDLs) strategy. The target compounds were synthesised and evaluated by AChE/BuChE inhibition and anti-inflammatory property. The in vitro activiti...