Optimized Signal Peptide for Secretory Expression of Human Recombinant Somatropin in E. coli

• Main Authors: Zeynab Ahmadi (Author), Safar Farajnia (Author), Davoud Farajzadeh (Author), Naser Pouladi (Author), Neda Pourvatan (Author), Mohammad Karbalaeimahdi (Author), Fahime Shayegh (Author), Maryam Arya (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The human somatropin is a single-chain polypeptide with a pivotal role in various biological processes. Although Escherichia coli is considered as a preferred host for the production of human somatropin, the high expression of this protein in E. coli results in the accumulation of protein a...