Development of a Facile Approach for Generating Chemically Modified CRISPR/Cas9 RNA
The RNA-guided, modified type II prokaryotic CRISPR with CRISPR-associated proteins (CRISPR/Cas9) system represents a simple gene-editing platform with applications in biotechnology and also potentially as a therapeutic modality. The system requires a small guide RNA (sgRNA) and a catalytic Cas9 pro...
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Elsevier,
2020-03-01T00:00:00Z.
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