Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

• Main Authors: Benjamin P. Tooke (Author), Hui Yu (Author), Jessica M. Adams (Author), Graham L. Jones (Author), Talisha Sutton-Kennedy (Author), Lakshmi Mundada (Author), Nathan R. Qi (Author), Malcolm J. Low (Author), Kavaljit H. Chhabra (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Life-threatening hypoglycemia is a major limiting factor in the management of diabetes. While it is known that counterregulatory responses to hypoglycemia are impaired in diabetes, molecular mechanisms underlying the reduced responses remain unclear. Given the established roles of the hyp...