Discontinuation of tyrosine kinase inhibitors based on BCR-ABL1 monitoring by digital droplet PCR in pediatric chronic myeloid leukemia

• Main Authors: Yeojae Kim (Author), Seongkoo Kim (Author), Jong Mi Lee (Author), Ari Ahn (Author), Jae Won Yoo (Author), Jae Wook Lee (Author), Bin Cho (Author), Nack-Gyun Chung (Author), Yonggoo Kim (Author), Myungshin Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lifelong treatment of pediatric chronic myeloid leukemia (CML) patients with tyrosine kinase inhibitors (TKIs) can affect their growth and development. For these reasons, clinical trials have explored the feasibility of TKI discontinuation in children with a sufficient TKI response. We evaluated the...