Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

• Главные авторы: Ha Thi Ngo (Автор), Ragna Bogen Hetland (Автор), Unni Cecilie Nygaard (Автор), Inger-Lise Steffensen (Автор)
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• Опубликовано: Hindawi Limited, 2015-01-01T00:00:00Z.
• Предметы: article
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We have studied how spontaneous or carcinogen-induced intestinal tumorigenesis was affected by genetic or diet-induced obesity in C57BL/6J-ApcMin/+ X C57BL/6J-Lepob/+ mice. Obesity was induced by the obese (ob) mutation in the lep gene coding for the hormone leptin, or by a 45% fat diet. The effects...