Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems

• Main Authors: Kanghee Jo (Author), Hyeongmin Kim (Author), Prakash Khadka (Author), Taejun Jang (Author), Soo Jin Kim (Author), Seong-Ha Hwang (Author), Jaehwi Lee (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated self-microemulsifying drug delivery syst...