Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury

• Main Authors: Shiyun Pu (Author), Qinhui Liu (Author), Yanping Li (Author), Rui Li (Author), Tong Wu (Author), Zijing Zhang (Author), Cuiyuan Huang (Author), Xuping Yang (Author), Jinhan He (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure. Montelukast is an antagonist of cysteinyl leukotriene receptor 1 (Cysltr1), which protects from inflammation and oxidative stres...