Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Me2DO2A on Experimental Articular Pain in Rats

• Main Authors: Lorenzo Di Cesare Mannelli (Author), Daniele Bani (Author), Andrea Bencini (Author), Maria Luisa Brandi (Author), Laura Calosi (Author), Miriam Cantore (Author), Anna Maria Carossino (Author), Carla Ghelardini (Author), Barbara Valtancoli (Author), Paola Failli (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Superoxide anion () is overproduced in joint inflammation, rheumatoid arthritis, and osteoarthritis. Increased production leads to tissue damage, articular degeneration, and pain. In these conditions, the physiological defense against , superoxide dismutases (SOD) are decreased. The complex MnL4 is...