Design, synthesis, and biological characterization of a potent STAT3 degrader for the treatment of gastric cancer

• Main Authors: Haobin Li (Author), Lingling Wang (Author), Fei Cao (Author), Dehua Yu (Author), Jing Yang (Author), Xuefei Yu (Author), Jinyun Dong (Author), Jiang-Jiang Qin (Author), Xiaoqing Guan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastric cancer is a common malignant tumor that threatens human health, and its occurrence and development mechanism is a complex process involving multiple genes and multiple signals. Signal transducer and activator of transcription 3 (STAT3) has been elucidated as a promising target for developing...