Betulin-3,28-diphosphate as a Component of Combination Cytostatic Drugs for the Treatment of Ehrlich Ascites Carcinoma In Vitro and In Vivo Experiments

• Main Authors: Olga Vorobyova (Author), Olga Deryabina (Author), Darina Malygina (Author), Nadezhda Plotnikova (Author), Anna Solovyeva (Author), Kseniya Belyaeva (Author), Nina Melnikova (Author)
• Format: Book
• Published: MDPI AG, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activity of betulin-3,28-diphosphate (BDP) in combination with the cytostatics such as 5-fluorouracil (5-FU) and hydrazine sulfate (HS) was demonstrated by using the transplanted Ehrlich ascites carcinoma (EAC) in mice. The dose-dependent effect of combination drugs BDP + HS and BDP + 5-FU was r...