In vivo / in vitro Correlation of Pharmacokinetics of Gentamicin, Vancomycin, Teicoplanin and Doripenem in a Bovine Blood Hemodialysis Model

• Main Authors: M G Vossen (Author), S Pferschy (Author), C Milacek (Author), M Haidinger (Author), Mario Karolyi (Author), Zoltan Vass (Author), Heinz Burgmann (Author), Alexandra Maier-Salamon (Author), S G Wicha (Author), W Jäger (Author), M Zeitlinger (Author), T Stimpfl (Author), T Wittek (Author), F Thalhammer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Elimination of a drug during renal replacement therapy is not only dependent on flow rates, molecular size and protein binding, but is often influenced by difficult to predict drug membrane interactions. In vitro models allow for extensive profiling of drug clearance using a wide array o...