Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release

• Main Authors: Yang Yang (Author), Fuwei Yang (Author), Xiaotian Shan (Author), Jiamin Xu (Author), Wenjie Fang (Author), Juan Zhou (Author), Lipeng Qiu (Author), Jinghua Chen (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

At present, the drug is still difficult to release completely and quickly only with single stimulation. In order to promote the rapid release of polymeric micelles at tumor site, pH/reduction sensitive polymers (PCT) containing disulfide bonds and orthoester groups were synthesized. The PCT polymers...