Evaluating the performance of machine‐learning regression models for pharmacokinetic drug-drug interactions

• Main Authors: Jaidip Gill (Author), Marie Moullet (Author), Anton Martinsson (Author), Filip Miljković (Author), Beth Williamson (Author), Rosalinda H. Arends (Author), Venkatesh Pilla Reddy (Author)
• Formato: Livro
• Publicado em: Wiley, 2023-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Combination therapy or concomitant drug administration can be associated with pharmacokinetic drug-drug interactions, increasing the risk of adverse drug events and reduced drug efficacy. Thus far, machine‐learning models have been developed that can classify drug-drug interactions. However...