A Mixed-Surface Polyamidoamine Dendrimer for In Vitro and In Vivo Delivery of Large Plasmids

• Main Authors: Bhairavi Srinageshwar (Author), Maria Florendo (Author), Brittany Clark (Author), Kayla Johnson (Author), Nikolas Munro (Author), Sarah Peruzzaro (Author), Aaron Antcliff (Author), Melissa Andrews (Author), Alexander Figacz (Author), Douglas Swanson (Author), Gary L. Dunbar (Author), Ajit Sharma (Author), Julien Rossignol (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug delivery to the brain is highly hindered by the presence of the blood-brain barrier (BBB), which prevents the entry of many potential drugs/biomolecules into the brain. One of the current strategies to achieve gene therapy for neurodegenerative diseases involves direct injection of a viral vect...