GH dysfunction in Engrailed-2 knockout mice, a model for autism spectrum disorders

• Main Authors: Giovanni eProvenzano (Author), Elena eClementi (Author), Sacha eGenovesi (Author), Manuela eScali (Author), Prem Prakash Tripathi (Author), Paola eSgadò (Author), Yuri eBozzi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin-like growth factor 1 (IGF-1) signaling promotes brain development and plasticity. Altered IGF-1 expression has been associated to autism spectrum disorders (ASD). IGF-1 levels were found increased in the blood and decreased in the cerebrospinal fluid of ASD children. Accordingly, IGF-1 treat...