GH dysfunction in Engrailed-2 knockout mice, a model for autism spectrum disorders

• Egile Nagusiak: Giovanni eProvenzano (Egilea), Elena eClementi (Egilea), Sacha eGenovesi (Egilea), Manuela eScali (Egilea), Prem Prakash Tripathi (Egilea), Paola eSgadò (Egilea), Yuri eBozzi (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2014-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Insulin-like growth factor 1 (IGF-1) signaling promotes brain development and plasticity. Altered IGF-1 expression has been associated to autism spectrum disorders (ASD). IGF-1 levels were found increased in the blood and decreased in the cerebrospinal fluid of ASD children. Accordingly, IGF-1 treat...