GH dysfunction in Engrailed-2 knockout mice, a model for autism spectrum disorders

• Glavni autori: Giovanni eProvenzano (Autor), Elena eClementi (Autor), Sacha eGenovesi (Autor), Manuela eScali (Autor), Prem Prakash Tripathi (Autor), Paola eSgadò (Autor), Yuri eBozzi (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2014-09-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Insulin-like growth factor 1 (IGF-1) signaling promotes brain development and plasticity. Altered IGF-1 expression has been associated to autism spectrum disorders (ASD). IGF-1 levels were found increased in the blood and decreased in the cerebrospinal fluid of ASD children. Accordingly, IGF-1 treat...