Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis

• Main Authors: Meiling Wang (Author), Hongyan Li (Author), Yanfang Wang (Author), Yanfei Hao (Author), Yanan Huang (Author), Xinlin Wang (Author), Yongying Lu (Author), Yuan Du (Author), Fenghua Fu (Author), Wenyu Xin (Author), Leiming Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is among the most prevalent forms of autoimmunity. Gentiopicroside (Gent) is an iridoid glucoside derived from the Gentiana Macrophylla Pall which is used in traditional Chinese medicine to treat RA. The present study was designed to explore the ability of Gent to combat RA...