A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression

• Autors principals: Ting Wang (Autor), Jingjing Dong (Autor), Xu Yuan (Autor), Haotian Wen (Autor), Linguangjin Wu (Autor), Jianwen Liu (Autor), Hua Sui (Autor), Wanli Deng (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: C49 is a chalcone derivative. The aim of the current study is to illuminate the efficacy of C49 in reversing multidrug resistance (MDR) in MCF-7/DOX cells and its underlying molecular mechanism.Methods: The cytotoxic effects of C49 on MCF-7/DOX cells were evaluated by MTT assay using diff...