Influence of NOD2 Variants on Trichuris suis ova Treatment Outcome in Crohn's Disease

• Main Authors: Simon U. Jaeger (Author), Elke Schaeffeler (Author), Stefan Winter (Author), Roman Tremmel (Author), Jürgen Schölmerich (Author), Nisar Malek (Author), Eduard F. Stange (Author), Matthias Schwab (Author), Jan Wehkamp (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A recent randomized study of whipworm Trichuris suis ova (TSO) in ileal Crohn's disease failed to demonstrate a clinical benefit compared to placebo after 12 weeks. Nonetheless, it has recently been shown that the spontaneous small intestinal inflammatory changes in Nod2-/- (Nucleotide-binding...