Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition

• Main Authors: Xiao-Jun Li (Author), Ping Suo (Author), Yan-Ni Wang (Author), Liang Zou (Author), Xiao-Li Nie (Author), Ying-Yong Zhao (Author), Hua Miao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified AA is hydrolysed by phospholipase A2 into a free form that is further metabolized by COX, LOX and CYP450 to...