Hirsutanol A Induces Apoptosis and Autophagy via Reactive Oxygen Species Accumulation in Breast Cancer MCF-7 Cells

• Main Authors: Fen Yang (Author), Wen-Dan Chen (Author), Rong Deng (Author), Dan-Dan Li (Author), Ke-Wei Wu (Author), Gong-Kan Feng (Author), Hou-Jin Li (Author), Xiao-Feng Zhu (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hirsutanol A is a novel sesquiterpene compound purified from the marine fungus Chondrostereum sp in the coral Sarcophyton tortuosum. Our previous studies had demonstrated that hirsutanol A exerted potent cytotoxic effect in many kinds of cancer cell lines. Here, the anticancer molecular mechanisms o...