Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers

• Main Authors: Graciela Cárdenas (Author), Raúl J. Bobes (Author), Gladis Fragoso (Author), Nicolas I. Pérez-Osorio (Author), Marisela Hernández (Author), Alejandro Espinosa (Author), Agnes Fleury (Author), José Flores (Author), The Revival Project Consortium (Author), Juan Pedro Laclette (Author), Edda Sciutto (Author), Helgi Jung-Cook (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dexamethasone (DXM) and methylprednisolone (MEP) are potent glucocorticoids used to control several inflammatory conditions. Evidence of delayed DXM reaching the central nervous system (CNS) as well as tachyphylaxis and systemic, undesirable side effects are the main limitations of peripheral delive...