Deletion of β-Arrestin2 in Mice Limited Pancreatic β-Cell Expansion under Metabolic Stress through Activation of the JNK Pathway

• Main Authors: Ziwei Lin (Author), Yu Zhao (Author), Lige Song (Author), Kaida Mu (Author), Mingliang Zhang (Author), Hongxia Liu (Author), Xiaowen Li (Author), Jian Zhao (Author), Chen Wang (Author), Weiping Jia (Author)
• Format: Book
• Published: BMC, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract β-Arrestin2 (βarr2) is an adaptor protein that interacts with numerous signaling molecules and regulates insulin sensitivity. We reported previously that βarr2 was abundantly expressed in mouse pancreatic β-cells, and loss of βarr2 leads to impairment of acute- and late-phase insulin secret...