Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease

• Główni autorzy: Junjiao Wu (Autor), Jie Ren (Autor), Hongfei Cui (Autor), Yali Xie (Autor), Yu Tang (Autor)
• Format: Książka
• Wydane: BMC, 2024-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background Different neural subtypes are selectively lost in diverse neurodegenerative diseases. Huntington's disease (HD) is an inherited neurodegenerative disease characterized by motor abnormalities that primarily affect the striatum. The Huntingtin (HTT) mutation involves an expand...