CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

• Main Authors: Yihui Chen (Author), Michela Capello (Author), Mayrim V. Rios Perez (Author), Jody V. Vykoukal (Author), David Roife (Author), Ya'an Kang (Author), Laura R. Prakash (Author), Hiroyuki Katayama (Author), Ehsan Irajizad (Author), Alia Fleury (Author), Sammy Ferri-Borgogno (Author), Dodge L. Baluya (Author), Jennifer B. Dennison (Author), Kim-Anh Do (Author), Oliver Fiehn (Author), Anirban Maitra (Author), Huamin Wang (Author), Paul J. Chiao (Author), Matthew H.G. Katz (Author), Jason B. Fleming (Author), Samir M. Hanash (Author), Johannes F. Fahrmann (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects, and contribution to tumor de...