Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice

• المؤلفون الرئيسيون: Kanikkai Raja Aseer (مؤلف), Caio Henrique Mazucanti (مؤلف), Jennifer F. O'Connell (مؤلف), Isabel González-Mariscal (مؤلف), Anjali Verma (مؤلف), Qin Yao (مؤلف), Christopher Dunn (مؤلف), Qing-Rong Liu (مؤلف), Josephine M. Egan (مؤلف), Máire E. Doyle (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2024-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Objective: Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that beta cell dysfunction partakes in this process. We previously reported that genetic deletion and pharmacological antagonism of the c...