Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice

• Main Authors: Kanikkai Raja Aseer (Author), Caio Henrique Mazucanti (Author), Jennifer F. O'Connell (Author), Isabel González-Mariscal (Author), Anjali Verma (Author), Qin Yao (Author), Christopher Dunn (Author), Qing-Rong Liu (Author), Josephine M. Egan (Author), Máire E. Doyle (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of beta cells and it is becoming evident that beta cell dysfunction partakes in this process. We previously reported that genetic deletion and pharmacological antagonism of the c...