Estrogen deprivation and estrogen receptor α antagonism decrease DSS colitis in female mice

• Main Authors: Anja Hjelt (Author), Santeri Anttila (Author), Anu Wiklund (Author), Anne Rokka (Author), Darin Al‐Ramahi (Author), Diana M. Toivola (Author), Lauri Polari (Author), Jorma Määttä (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The association of hormonal contraception with increased risk of inflammatory bowel disease (IBD) observed in females suggests involvement of ovarian hormones, such as estradiol, and the estrogen receptors in the progression of intestinal inflammation. Here, we investigated the effects of p...