Discovery of a new class of triazole based inhibitors of acetyl transferase KAT2A

• Main Authors: Roberta Pacifico (Author), Nunzio Del Gaudio (Author), Guglielmo Bove (Author), Lucia Altucci (Author), Lydia Siragusa (Author), Gabriele Cruciani (Author), Menotti Ruvo (Author), Rosa Bellavita (Author), Paolo Grieco (Author), Mauro F. A. Adamo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and validated for drug discovery and development. This study...