Hyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats

• Main Authors: Yu Lin (Author), Wenyu Du (Author), Xiangyu Fu (Author), Ling Huang (Author), Yiwen Hong (Author), Haishan Tan (Author), Lirong Xiao (Author), Xiang Ren (Author), Yujiao Wang (Author), Danian Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Chemicals, such as MNU (N-methyl-N-nitrosourea) and NaIO3 (sodium iodate), are widely used to induce retinal degeneration in rodents. Streptozotocin (STZ) is an analog of N-acetyl glucosamine in which an MNU moiety is linked to a hexose and has a special toxic effect on insulin-produci...