Influence of Age and Sex on the Pharmacokinetics of Midazolam and the Depth of Sedation in Pediatric Patients Undergoing Minor Surgeries

• Main Authors: Carmen Flores-Pérez (Author), Janett Flores-Pérez (Author), Luis Alfonso Moreno-Rocha (Author), Juan Luis Chávez-Pacheco (Author), Norma Angélica Noguez-Méndez (Author), Blanca Ramírez-Mendiola (Author), Yolopsi Sánchez-Maza (Author), Lina Sarmiento-Argüello (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Whether age and sex influence the depth of sedation and the pharmacokinetics of midazolam is currently unknown. The influence of age and sex was investigated in 117 children (2 to 17 years) who required intravenous sedation for minor surgery (0.05 mg/kg). Plasma concentrations and sedation effects w...