Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a diverse subset of the Pfizer corporate collection agai...
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| Main Authors: | , , , , , , , , , |
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| Format: | Book |
| Published: |
Public Library of Science (PLoS),
2012-01-01T00:00:00Z.
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