β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis

• Main Authors: Di Zhang (Author), Fei Ge (Author), Jing Ji (Author), Yu-Jing Li (Author), Fu-Rong Zhang (Author), Shu-Yan Wang (Author), Shu-Jing Zhang (Author), Dong-Mei Zhang (Author), Meng Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Inflammation-related NLRP3/Caspase-1/GSDMD-mediated pyroptosis is involved in the progression of ulcerative colitis (UC). β-sitosterol (SIT) was reported to have anti-inflammatory effects on experimental colitis, while the regulation of SIT on pyroptosis is unclear. Therefore, the presen...