Overexpression of EspL inhibits autophagy and antigen presentation to promote the intracellular survival of Mycobacterium tuberculosis avirulent strains

• Main Authors: Luxia Cai (Author), Yingying Lei (Author), Tianyi Xie (Author), Yiling Liu (Author), Yutong Fan (Author), Bing Yang (Author), Shuang Dong (Author), Gang Cao (Author), Xi Chen (Author)
• Format: Book
• Published: BMC, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mycobacterium tuberculosis (Mtb) employs multiple mechanisms, such as phagocytosis and autophagy, to evade innate immune clearance and establish infection. In the present study, we identified the ESX-1 secretion-associated protein EspL, which promotes Mtb survival by inhibiting phagosome ma...