Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

• Main Authors: Md Kabir (Author), Elias C. Padilha (Author), Pranav Shah (Author), Ruili Huang (Author), Srilatha Sakamuru (Author), Eric Gonzalez (Author), Lin Ye (Author), Xin Hu (Author), Mark J. Henderson (Author), Menghang Xia (Author), Xin Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various cancer patients. The characterization of CYP3A7 is...