Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

• Hauptverfasser: Md Kabir (Verfasst von), Elias C. Padilha (Verfasst von), Pranav Shah (Verfasst von), Ruili Huang (Verfasst von), Srilatha Sakamuru (Verfasst von), Eric Gonzalez (Verfasst von), Lin Ye (Verfasst von), Xin Hu (Verfasst von), Mark J. Henderson (Verfasst von), Menghang Xia (Verfasst von), Xin Xu (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Schlagworte: article
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Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various cancer patients. The characterization of CYP3A7 is...