Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment

• Main Authors: Linda Omer (Author), Lubna Hindi (Author), Giuseppe Militello (Author), Katlin B. Stivers (Author), Kenneth C. Tien (Author), Nolan L. Boyd (Author)
• Format: Bog
• Udgivet: The Company of Biologists, 2020-04-01T00:00:00Z.
• Fag: article
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Low-density lipoprotein (LDL) receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). Class II LDLR mutations result in a misfolded LDLR retained in the endoplasmic reticulum (ER). We have developed a model of FH class II and CRISPR-corrected induced pluripotent stem c...