Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment
Low-density lipoprotein (LDL) receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). Class II LDLR mutations result in a misfolded LDLR retained in the endoplasmic reticulum (ER). We have developed a model of FH class II and CRISPR-corrected induced pluripotent stem c...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2020-04-01T00:00:00Z.
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