NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients

• Main Authors: Xiang Fei (Author), Qing Shu (Author), Huaijun Zhu (Author), Bingzhu Hua (Author), Shiying Wang (Author), Ling Guo (Author), Yun Fang (Author), Weihong Ge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Among 87 enrolled patients, 23 (26.4%) had leukopenia. The NUDT15 R139C variant was associated with leukop...