BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

• Main Authors: Jenny M. Hoffmann (Author), John R. Grünberg (Author), Ann Hammarstedt (Author), Tobias Kroon (Author), Thomas U. Greiner (Author), Stefanie Maurer (Author), Ivet Elias (Author), Vilborg Palsdottir (Author), Fatima Bosch (Author), Jeremie Boucher (Author), Shahram Hedjazifar (Author), Ulf Smith (Author)
• Format: Book
• Published: Elsevier, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we exam...