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BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we exam...

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Main Authors: Jenny M. Hoffmann (Author), John R. Grünberg (Author), Ann Hammarstedt (Author), Tobias Kroon (Author), Thomas U. Greiner (Author), Stefanie Maurer (Author), Ivet Elias (Author), Vilborg Palsdottir (Author), Fatima Bosch (Author), Jeremie Boucher (Author), Shahram Hedjazifar (Author), Ulf Smith (Author)
Format: Book
Published: Elsevier, 2020-02-01T00:00:00Z.
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