TRAF-STOP alleviates osteoclastogenesis in periodontitis

• Main Authors: Yaxian Huang (Author), Jinyan Wu (Author), Chi Zhan (Author), Rong Liu (Author), Zhaocai Zhou (Author), Xin Huang (Author), Yaguang Tian (Author), Zhengmei Lin (Author), Zhi Song (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The enhanced osteoclastogenesis contributes to alveolar bone resorption in periodontitis, which increases the risk of tooth loss. To reduce bone destruction, the inhibition of osteoclast development is proposed as a feasible treatment. CD40L-CD40-TRAF6 signal transduction plays a crucial role in inf...