Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia

• Main Authors: Miao Tang (Author), Shuang Zhao (Author), Jia-Xin Liu (Author), Xin Liu (Author), Yue-Xian Guo (Author), Gui-Ying Wang (Author), Xiu-Li Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Paclitaxel (PTX) leads to chemotherapy brain (chemo-brain) which is characterised by cognitive impairment. It has been reported that necroptosis is associated with cognitive impairment in some neurodegenerative diseases, but it is not clear whether it is related to the development of chemo-b...