Clinical and parasitological protection in a Leishmania infantum-macaque model vaccinated with adenovirus and the recombinant A2 antigen.

• Main Authors: Gabriel Grimaldi (Author), Antonio Teva (Author), Renato Porrozzi (Author), Marcelo A Pinto (Author), Renato S Marchevsky (Author), Maria Gabrielle L Rocha (Author), Miriam S Dutra (Author), Oscar Bruña-Romero (Author), Ana-Paula Fernandes (Author), Ricardo T Gazzinelli (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Visceral leishmaniasis (VL) is a severe vector-born disease of humans and dogs caused by Leishmania donovani complex parasites. Approximately 0.2 to 0.4 million new human VL cases occur annually worldwide. In the new world, these alarming numbers are primarily due to the impracticality o...