Sodium Tanshinone IIA Sulfonate as a Potent IDO1/TDO2 Dual Inhibitor Enhances Anti-PD1 Therapy for Colorectal Cancer in Mice

• Asıl Yazarlar: Rongjie Zhang (Yazar), Yuanfeiyi Wang (Yazar), Dan Liu (Yazar), Qing Luo (Yazar), Peixin Du (Yazar), Haiyan Zhang (Yazar), Wenshuang Wu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Although the antitumor efficacy of immune checkpoint blockade (ICB) has been proved in colorectal cancer (CRC), the results are unsatisfactory, presumably owing to the presence of tryptophan metabolism enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2). However, onl...