IFN-γ production depends on IL-12 and IL-18 combined action and mediates host resistance to dengue virus infection in a nitric oxide-dependent manner.

• Main Authors: Caio T Fagundes (Author), Vivian V Costa (Author), Daniel Cisalpino (Author), Flávio A Amaral (Author), Patrícia R S Souza (Author), Rafael S Souza (Author), Bernhard Ryffel (Author), Leda Q Vieira (Author), Tarcília A Silva (Author), Alena Atrasheuskaya (Author), George Ignatyev (Author), Lirlândia P Sousa (Author), Danielle G Souza (Author), Mauro M Teixeira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue is a mosquito-borne disease caused by one of four serotypes of Dengue virus (DENV-1-4). Severe dengue infection in humans is characterized by thrombocytopenia, increased vascular permeability, hemorrhage and shock. However, there is little information about host response to DENV infection. He...