Bioequivalence of Two Intravenous Artesunate Products with Its Active Metabolite Following Single and Multiple Injections

• मुख्य लेखकों: Qigui Li (लेखक), Lisa Xie (लेखक), Peter Weina (लेखक), Victor Melendez (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2011-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In animal species and humans, artesunate (AS) undergoes extensive and complex biotransformation to an active metabolite, dihydroartemisinin (DHA). The bioequivalence of two intravenous AS pharmaceutical products with 5% NaHCO3 (China Formulation) or 0.3 M PBS (WRAIR Formulation) was determined in ra...