Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

• मुख्य लेखकों: Laura Maria Fuhr (लेखक), Fatima Zahra Marok (लेखक), Nina Hanke (लेखक), Dominik Selzer (लेखक), Thorsten Lehr (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other hand, its metabolism can be affected by vario...