Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

• Hauptverfasser: Laura Maria Fuhr (Verfasst von), Fatima Zahra Marok (Verfasst von), Nina Hanke (Verfasst von), Dominik Selzer (Verfasst von), Thorsten Lehr (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-02-01T00:00:00Z.
• Schlagworte: article
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The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other hand, its metabolism can be affected by vario...