Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach

• Автори: Laura Maria Fuhr (Автор), Fatima Zahra Marok (Автор), Nina Hanke (Автор), Dominik Selzer (Автор), Thorsten Lehr (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2021-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. Carbamazepine induces the metabolism of various drugs (including its own); on the other hand, its metabolism can be affected by vario...